Gad Getz directs the Cancer Genome Computational Analysis group at the Broad Institute of MIT and Harvard, where he is a core institute member. Under Getz’s leadership, the Cancer Genome Analysis group has established itself as a world leader in the development and application of genomic technologies and next-generation sequencing for analyzing cancer mutations.
In addition to his role at the Broad, Getz is a co-PI of the primary The Cancer Genome Analysis (TCGA) Genome Data Analysis Center (GDAC) and leads this effort at the Broad; he is also a co-PI of the Broad’s Proteogenomics Data Analysis Center. He has been involved in numerous large-scale cancer genome projects such as the Tumor Sequencing Project (TSP) and the TCGA project (both pilot and extension), which generated and analyzed data from over ~10,000 samples of various cancers, using multiple profiling platforms. Getz has also been a co-leader of the international effort for pan-cancer analysis of whole genomes (PCAWG) as part of a joint effort between TCGA and the International Cancer Genome Consortium (ICGC); was a member of the NCI’s Cancer Moonshot Blue Ribbon Panel; and co-led one of three NCI Cloud Pilots. He has published numerous papers in prominent journals describing new methodologies to study cancer genomes that have identified new genes and pathways involved in different tumor types, mutational signatures, and tumor evolution. His lab is currently interested in studying the heterogeneity and clonal evolution of many types of different cancers; single-cell analysis of tumors and the tumor microenvironment; drivers of resistance to therapies; the proteogenomic analysis of tumors; the role of somatic mutations in normal tissues; and other facets of the cancer genome.
Getz received his B.S. degree in physics and mathematics from Hebrew University and an M.Sc. in physics from Tel-Aviv University. He later earned a Ph.D. in physics from the Weizmann Institute of Science in Israel. He completed his postdoctoral training at the Broad Institute of MIT and Harvard with Todd Golub, where he focused on developing computational tools and analyzing expression of miRNAs across cancer.
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Mouhieddine TH, Nzerem C, [...], Sperling AS, Stewart C, Getz G
Cancer Res Commun
(2023).
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Li Y, Porta-Pardo E, Tokheim C, Bailey MH, Yaron TM, [...], Ding L
Cell
(2023).
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Geffen Y, Anand S, Akiyama Y, Yaron TM, Song Y, [...], Getz G
Cell
(2023).
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Li Y, Dou Y, Da Veiga Leprevost F, Geffen Y, Calinawan AP, [...], Robles AI, Zhang B, Payne SH
Cancer Cell
(2023).
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Khalsa JK, Cha J, Utro F, Naeem A, Murali I, [...], Parida L, Getz G, Brown JR
Blood
(2023).
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Leshchiner I, Mroz EA, Cha J, [...], Getz G, Rocco JW
Nature Cancer
(2023).
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Ravi A, Hellmann MD, Arniella MB, [...], Hacohen N, Getz G, Gainor JF
Nature Genetics
(2023).
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Parry EM, Leshchiner I, Guièze R, [...], Stilgenbauer S, Getz G, Wu CJ
Nature Medicine
(2023).
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Dutta AK, Alberge JB, [...], Getz G, Ghobrial IM
Cancer Discovery
(2022).
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Boiarsky R, [...], Sontag D, Ghobrial IM, Getz G
Nature Communicatiopns
(2022).
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Sklavenitis-Pistofidis R, [...], Getz G, Ghobrial IM
Cancer Cell
(2022).
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Naeem A, [...], Zain R, Smith CIE, Leshchiner I, Parida L, Getz G, Brown JR
Blood Advances
(2022).
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Tsuji J, [...], Getz G, Jeselsohn R
Clinical Cancer Research
(2022).
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Haradhvala NJ, Leick MB, Maurer K, Gohil SH, [...], Wu CJ, Getz G, Maus MV
Nature Medicine
(2022).
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Gao GF, Oh C, Saksena G, [...], Meyerson M, Tabak B, Beroukhim R, Getz G
Bioinformatics
(2022).
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Roh W, Geffen Y, Cha H, [...], Lee SH, Getz G
Cancer Research
(2022).
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Knisbacher BA, Lin Z, Hahn CK, Nadeu F, Duran-Ferrer M, [...], Martín-Subero JI, Puente XS, Stilgenbauer S, Wu CJ, Campo E, Getz G
Nature Genetics
(2022).
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Bustoros M, Anand S, [...], Getz G, Ghobrial IM
Nature Communications
(2022).
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El-Khoury H, Lee DJ, Alberge JB, [...], Getz G, Marinac CR, Ghobrial IM
Lancet Haematology
22
(2022).
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Freeman SS, Sade-Feldman M, [...], Getz G, Hacohen N
Cell Reports Medcine
3
(2)
(2022).
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Beauchamp EM, [...], Jaiswal S, Ebert BL
Blood Cancer Discovery
2
(5)
500-517
(2021).
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Coates JT, Sun S, [...], Bardia A, Ellisen LW
Cancer Discovery
11
(10)
2436-2445
(2021).
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Sklavenitis-Pistofidis R, Haradhvala NJ, [...], Getz G, Ghobrial I
Nature Immunology
22
677-678
(2021).
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Morton L, Karyadi D, Stewart C, [...], Getz G, Chanock S
Science
(April)
(2021).
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Dentro SC, Leshchiner I, Haase K, Tarabichi M, Wintersinger J, Deshwar AG, Yu K, Rubanova Y, Macintyre G, Demulemeester J, [...], Wang W, Morris QD, Wedge DC, Van Loo P
Cell
184
(8)
2239-2254
(2021).
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Sklavenitis-Pistofidis R, [...], Getz G, Ghobrial I
Nature Medicine
(27)
375-376
(2021).
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Graubert A, [...], Getz G
Bioinformatics
(2021).
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Hong X, Roh W, [...], Maheswaran S, Haber DA
Cancer Discovery
11
(3)
678-695
(2021).
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Chung J, Maruvka YE, [...], Getz G, Tabori U
Cancer Discovery
(2020).
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Vidula N, Dubash T, [...], Haber DA, Bardia A
Clinical Cancer Research
26
(18)
4852-3862
(2020).
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Busteros M, Sklavenitis-Pistofidis R, [...], Manier S, Getz G, Ghobrial IM
Journal of Clinical Oncology
38
(21)
2380-2389
(2020).
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Ben-Hamo R, [...], Getz G, Straussman R
Nature Communciations
11
(1)
(2020).
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Mouhieddine TH, [...], Neuberg DS, Ghobrial IM
Nature Communications
11
2996
(2020).
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Rheinbay E, Nielsen MM, Abascal F, Wala JA, Shapira O, [...], Weischenfeldt J, Martincorena I, Pedersen JS, Getz G
Nature
578
(7793)
102-111
(2020).
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Zavidij O, Haradhvala NJ, Mouhieddine TH, [...], Azzi J, Getz G, Ghobrial IM
Nature Cancer
1
(5)
493-506
(2020).
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Alexandrov LB, Kim J, Haradhvala NJ, Huang MN, [...], Getz G, Rozen SG, Stratton MR
Nature
578
(7793)
94-101
(2020).
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Gerstung M, Jolly C, Leshchiner I, Dentro SC, Gonzalez S, [...], Spellman P, Wedge D, Van Loo P
Nature
578
(7793)
122-128
(2020).
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Chapuy B, Stewart C, Dunford AJ, [...], Getz G, Shipp MA
Blood
134
(26)
2369-2382
(2019).
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Wienand K, Chapuy B, Stewart C, Dunford AJ, Wu D, [...], Fromm JR, Getz G, Shipp MA
Blood Advances
3
(23)
4065-4080
(2019).
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Taylor-Weiner A, Aguet F, [...], Getz G
Genome Biology
20
(1)
(2019).
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Hess JM, [...], Lawrence MS, Getz G
Cancer Cell
36
(3)
288-301
(2019).
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Parikh AR, Leshchiner I, Elagina L, [...], Getz G, Corcoran RB
Nature Medicine
25
(9)
1415-1421
(2019).
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Yizhak K, [...], Getz G
Science
364
(6444)
(2019).
-
Kim J, [...], Lerner SP
European Urology
75
(6)
961-964
(2019).
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Gruber M, Bozic I, Leshchiner I, Livitz D, [...], Getz G, Wu CJ
Nature
570
(7762)
474-479
(2019).
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Leshchiner I, Livitz D, Gainor J, Rosebrock D, [...], Shaw A, Getz G
bioRxiv
(2019).
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Kübler K, Karlić R, [...], Foulkes WD, Polak P, Getz G
bioRxiv
(2019).
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Sade-Feldman M, Yizhak K, [...], Getz G, Hacohen N
Cell
175
(4)
998-1013.E20
(2018).
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Stewart C, Leshchiner I, [...], Getz G
Science
361
(6409)
(2018).
-
Gopal RK, Kübler K, [...], Getz G, McFadden DG
Cancer Cell
34
(2)
242-255.e5
(2018).
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Taylor-Weiner A, Stewart C, [...], Getz G
Nature Methods
15
(7)
531-534
(2018).
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Haradhvala NJ, Kim J, Maruvka YE, [...], Mouw KW, Lawrence MS, Getz G
Nature Communications
9
(1)
1746
(2018).
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Chapuy B, Stewart C, Dunford AJ, [...], Getz G, Shipp MA
Nature Medicine
24
(5)
679-690
(2018).
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Horn H, Lawrence MS, [...], Boehm JS, Getz G, Lage K
Nature Methods
15
(1)
61-66
(2017).
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Tiao G, Improgo MR, [...], Getz G, Brown JR
Blood
130
(22)
2443-2444
(2017).
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Adalsteinsson VA, Ha G, Freeman SS, [...], Getz G, Love JC, Meyerson M
Nature Communications
8
(1)
1324
(2017).
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Robertson AG, Kim J, [...], Weinstein JN, Kwiatkowski DJ, Lerner SP
Cell
171
(3)
540-556
(2017).
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Brastianos PK, Nayyar N, Rosebrock D, Leshchiner I, [...], Cahill DP, Getz G, Batchelor TT
Precision Oncology
1
(1)
(2017).
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Maruvka YE, [...], Getz G
Nature Biotechnology
35
(10)
951-959
(2017).
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Polak P, Kim J, Braunstein LZ, [...], Foulkes WD, Getz G
Nature Genetics
49
(10)
1476-1486
(2017).
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Rheinbay E, Parasuraman P, [...], Getz G
Nature
547
(7661)
55-60
(2017).
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Dunford A, Weinstock D, [...], Lawrence MS, Getz G, Lane AA
Nature Genetics
49
(1)
10-16
(2016).
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Kim J, Mouw KW, Polak P, [...], Getz G
Nature Genetics
48
(6)
600-606
(2016).
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Haradhvala NJ, Polak P, [...], Lawrence MS, Getz G
Cell
164
(3)
538-549
(2016).
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Kasar S, Kim J, [...], Getz G, Brown JR
Nature Communications
6
(2015).
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Landau DA, Tausch E, Taylor-Weiner AN, [...], Hallek M, Neuberg D, Getz G, Stilgenbauer S, Wu CJ
Nature
526
(7574)
525-530
(2015).
-
Kamburov A, [...], Lander ES, Getz G
PNAS
112
(40)
E5486-95
(2015).
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Brastianos PK, Carter SL, [...], Getz G, Hahn WC
Cancer Discovery
5
(11)
1164-1177
(2015).
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Shukla SA, [...], Wu CG, Getz G
Nature Biotechnology
33
(11)
1152-1158
(2015).
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Ramos AH, [...], Meyerson M, Getz G
Human Mutation
36
(4)
E2423-9
(2015).
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Perry JA, Kiezun A, [...], Getz G, Janeway KA
PNAS
111
(51)
E5564-73
(2014).
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Landau DA, Clement K, [...], Getz G, Meissner A, Wu CJ
Cancer Cell
26
(6)
813-825
(2014).
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Crompton BD, Stewart C, [...], Getz G, Mora J, Stegmaier K
Cancer Discovery
4
(11)
1326-41
(2014).
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Yuan Y, Van Allen EM, Omberg L, [...], Garraway LA, Margolin AA, Getz G, Liang H
Nature Biotechnology
32
(7)
644-52
(2014).
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Van Allen EM, Wagle N, [...], Gabriel S, Getz G, Garraway LA
Nature Medicine
20
(6)
682-8
(2014).
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Lohr JG, Adalsteinsson VA, Cibulskis K, [...], Getz G, Boehm JS, Love JC
Nature Biotechnology
32
(5)
479-84
(2014).
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Torres-García W, Zheng S, Sivachenko A, [...], Getz G, Verhaak RG
Bioinformatics
30
(15)
2224-6
(2014).
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McFadden DG, Papagiannakopoulos T, Taylor-Weiner A, Stewart C, Carter SL, [...], Getz G, Jacks T
Cell
156
(6)
1298-1311
(2014).
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Lawrence MS, [...], Lander ES, Getz G
Nature
505
(7484)
495-501
(2014).
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Lohr JG, Stojanov P, Carter SL, [...], Getz G, Golub TR
Cancer Cell
25
(11)
91-101
(2014).
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Brastianos PK, Taylor-Weiner A, Manley PE, [...], Kieran MW, Getz G, Santagata S
Nature Genetics
46
(2)
161-5
(2014).
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Kim Y, Hammerman PS, Kim J, [...], Getz G, Meyerson M, Park K
Journal Clinical Oncology
32
(2)
121-8
(2014).
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Zack TI, Schumacher SE, [...], Getz G, Meyerson M, Beroukhim R
Nature Genetics
45
(10)
1134-40
(2013).
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Black JC, Manning AL, Van Rechem C, Kim J, [...], Getz G, Whetstine JR
Cell
154
(3)
541-55
(2013).
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Roberts SA, [...], Getz G, Gordenin DA
Nature Genetics
45
(9)
970-6
(2013).
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Lawrence MS, Stojanov P, Polak P, [...], Lander ES, Getz G
Nature
499
(7457)
214-218
(2013).
-
Costello M, [...], Getz G
Nucleic Acids Research
41
(6)
e67
(2013).
-
Cibulskis K, [...], Getz G
Nature Biotechnology
(3)
213-219
(2013).
-
Dulak AM, Stojanov P, [...], Getz G, Bass AJ
Nature Genetics
45
(5)
478-86
(2013).
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Landau DA, Carter SL, Stojanov P, [...], Getz G, Wu CJ
Cell
152
(4)
714-26
(2013).
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Drier Y, [...], Getz G
Genome Research
23
(2)
228-35
(2012).
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Lee RS, Stewart C, [...], Biegel JA, Getz G, Roberts CW
Journal of Clinical Investigation
122
(8)
2983-8
(2012).
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Banerji S, Cibulskis K, Rangel-Escareno C, [...], Toker A, Getz G, Hidalgo-Miranda A, Meyerson M
Nature
486
(7403)
405-9
(2012).
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Barbieri CE, Baca SC, Lawrence MS, [...], Getz G, Rubin MA, Garraway LA
Nature Genetics
44
(6)
685-9
(2012).
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Berger MF, Hodis E, Heffernan TP, Deribe YL, [...], Lander ES, Getz G, Chin L, Garraway LA
Nature
485
(7399)
502-6
(2012).
-
Carter SL, [...], Getz G
Nature Biotechnology
30
(5)
(2012).
-
DeLuca DS, [...], Getz G
Bioinformatics
28
(11)
1530-2
(2012).
-
Lohr J, [...], Golub TR
PNAS
109
(10)
3879-3884
(2012).
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Wang L, Lawrence MS, [...], Brown JR, Getz G, Wu CJ
The New England Journal of Medicine
365
(26)
2497-506
(2011).
-
Carter S., [...], Getz G
Nature Precedings
(2011).
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Cibulskis K, McKenna A, [...], Getz G
Bioinformatics
27
(18)
2601-2
(2011).
-
Bass AJ, Lawrence MS, [...], Getz G, Meyerson M
Nature Genetics
43
(10)
964-968
(2011).
-
Mermel CH, [...], Beroukhim R, Getz G
Genome Biology
12
(4)
(2011).
-
Chapman M, [...], Getz G, Golub TR
Nature
471
(7339)
467-472
(2011).
-
Meyerson M, Gabriel S, Getz G, [...], Meyerson M, Gabriel S, Getz G
Nature Reviews Genetics
11
(10)
685-96
(2010).
-
Beroukhim R, Mermel CH, [...], Lander ES, Getz G, Sellers WR, Meyerson M
Nature
463
(7283)
899-905
(2010).
-
Chiang DY, Getz G, [...], Lander ES
Nature Methods
6
(1)
99-103
(2009).
-
Ding L, Getz G, Wheeler DA, [...], Meyerson M, Wilson RK
Nature
455
(7216)
1069-75
(2008).
-
Beroukhim R, Getz G, [...], Lander ES, Mellinghoff IK, Sellers WR
PNAS
104
(50)
20007-12
(2007).
-
Weir BA, Woo MS, Getz G, [...], Meyerson M
Nature
450
(7171)
893-8
(2007).
-
Getz G, Höfling H, [...], Lander ES
Science
450
(7171)
893-8
(2007).
-
Lu JH, [...], Golub TR
Nature
435
(7043)
834-8
(2005).